Today i’m going to talk about acetaminophen or parse them all poisoning acetaminophen or an a style p emil phenol was introduced in 1955 and until now it’s one of the most widely used drugs acetaminophen is one of the non-steroidal anti fermented drugs used as antibiotic and a little sick but it’s anti-inflammatory effect is very weak let’s talk about the mechanism
Of action acetaminophen leads to the new a vision of cyclooxygenase enzyme mainly type 2 lead to decrease the prostaglandin it acts in both central nervous system and briefer nervous system in the central nervous system it calls decrease in the prostaglandin e2 which lowers the hypothalamic set point to reduce the fever and activation of the descending in it
A inhibitory serotonergic pathways to produce analgesia in the brief and nervous system it causes the crease in the prostaglandin h2 which is unstable intermediate that converted to a pro inflammatory compounds about the system fe metabolism the liver is the primary site in the body where the sniffing is metabolized 35% to 45 percent of the 17 first undergoes
Sulfation and 45 to 55 percent undergoes a judoka ideations before being eliminated from the body five percent is being eliminated by the renal system an excessive amount of the acetaminophen in the liver however can overwhelm the sulfation and the juvenile different pathways when this happens the acetaminophen is a persist through another pathway cytochrome b 450
What you produce an intermediate metabolite which called nebe qi and a style deep in the qin in a mine in epicure i is the toxic metabolite of the acetaminophen undergo detoxification by another pathway using the glutathione system to form non toxic compounds the cysteine and we kept uric acid this is the best way in case of normal dose of acetaminophen but in
Case of toxic dose the sulfate and shukran i bath ways becomes saturated result in an increased amount of acetaminophen being metabolized by cytochrome b 415 signs and once the glutathione stores are depleted may be qi begins to accumulate and cause hepatic injury from this diagram we can see one of the factors that could lead to the poisoning of a sniffing which
Are number one is the acetaminophen overdose it would cause more amount of the drug is being metabolized using so i think on beforehand 450 and morna bq is produced number two is the cytochrome p450 enzyme could be induced by many causes such as chronic alcoholism drugs anticonvulsant or anti tb or tobacco smoke number three is that the sulfation and the gherkin
Addition pathways become saturated such in case of malnourished and number four is the good a on the bleach in such in case of alcoholism so whatever the cause the result is more amount of nebulizer produced and more toxicity to the river thank you for watching and have a good time
Transcribed from video
Acetaminophen Poisoning By Wasim Issa
