A detail information regarding acetaminophen which includes indications, dosage regimen, mechanism of action, side effects, overdose, counselling tips.
Hello everyone welcome to drugs in detail this is my first video today i’m going to explain regarding paracetamol which is also called a stamina fen it is one of the world’s most used otc medication for pain it was first introduced in 1877 coming to indications of paracetamol that is used in mild to moderate pain and also in case of severe pain along with opioid
Along with opiate and it is also used in case reduction of fever coming to availability of dosage forms available in iv solutions extended willis tablet chewable tablet suppositories doublet current dose and two children who are less than 10 kg dose for administration 7.5 mg per kg and children who are between 10 to 30 3 kg dose per appreciation should be 15 mg
Per kg and also children who are 33 to 50 kg same 15 mg per kg and for greater than 50 kg that is 1 gram when it comes from maximum daily dose for children less than 10 kg maximum daily dose should be 30 mg per kg per day for between 10 to 33 kg at age 6 p mg per kg but the max to crunch and for children between 33 to 50 kg it is 60 mg per kg per day and 3 grams
Who are greater than 50 kg adults children or adults hence it is 4 grams mechanism of action of paracetamol first when it is antipyretic second dish an altruistic two mechanisms we should talk about paracetamol here one is inhibition of cox enzyme which in turn in habit prosper gland in synthesis second one cerato genic pathway activation it leads to activation of
Serotonin receptor which in turn decoration the pain threshold metabolism of paracetamol it undergoes clue quran id and sulfate conjugation a small amount of palace admin undergoes oxidation by cytochrome p450 enzyme and particularly by cytochrome p 2 e1 enzyme so to complete 2 e1 enzyme and results in n ap q i it is a reactive metabolite which is also called an
Acid lp bends up v9 a mine it reacts with glutathione and forms cysteine plus markup uric acid these are excreted in urine come to interactions parshat movin given with metoclopramide it results in bakery’s absorption because metoclopramide increase gastric and jing time so it increases absorption increase absorption and when it is given with opioids opioids
With paracetamol decrease absorption because opioids decrease gastric emptying time and caution should be taken while given with carbamazepine phenytoin which are enzyme inducers and alcohol should be avoided when pass at mothers taking and paracetamol along with warfarin that is studies which shows that there is an increase in inr so frequent testing or vienna
Should be done special population it can be administered in lactating and pregnant women in case of liver failure caution should be taken and renal failure gfr less than 30 ml per minute or equal to gosh should be decreased and in case of when paracetamol is taken in large doses which is 150 mg per kg door then it results in a kid hepatic necrosis which is
To do what glutathione is saturated so the reactive metabolite na pq i who reacts with liver cells results in acute hepatic necrosis symptoms of overdose renal tubular necrosis hypoglycemia coma thrombocytopenia what is the antidote in acid i’ll sustain compatibility of iv solution pin-compatible with a cyclo where diazepam and claude promising please remember
Desperate mothers not incompatible with acyclovir diazepam one ramazan it’s a big mixed with dextrose 5% in water or 0.9% sodium chloride at last side-effects i firmly if one of the most safest drug in some rare conditions it shows very normal side effects which include nausea vomiting in frontages insomnia and hide axiom which are more common side effects and
At last counseling points to patients when parasite mistaken alcohol should be avoided can be taken either with food oh without food and patient should avoid multiple product containing paracetamol i hope everyone understand well thank you for watching please like share subscribe braixen detail up to date with yours
Transcribed from video
Acetaminophen (Paracetamol) – Monograph By Drugs in DetailliveBroadcastDetails{isLiveNowfalsestartTimestamp2020-06-24T162052+0000endTimestamp2020-06-24T162431+0000}
