#Anticancer #Mechanism_of_Action_steroids | #tamoxifen #raloxifene |#aromatsae_inhibitors|#Dr_UUT_English
Welcome ladies and gentlemen in the last videos we discussed anti-cancer chemotherapy or you can say chemotherapy for the cancer now in this video we will discuss the steroids as usual videos are available both in urdu and english so this video is in english steroids we use two types of medications two types of procedures number one in the body likes to total hormones
Estrogen which are responsible for causing the cancer in the females will give both females the antagonist of battle estrogen to treat that cancer and some half we will take the best surgeon out from the body or will inhibit so like that the cancer might not proliferate the cancer might not cause further harm so there are two types what is hormone responsive tumor
And the one is tumor hormone-dependent chamber so however responsive tumor is that tumor in which if hormone is dispensed that was that would cause the regression of that tumor means that tumor will will be the regressor will be suppressed the amount of that tumor will be decreased there you can say the tumor is will be electric over the process of progression
And another tumor is available that is hormone-dependent in which what will we do either we will go through the surgical procedure to remove that hormone or will give the medication antagonist to decrease the effect of that on one we give you example of estrogen but is responsible for causing the cancer now is breast cancer first of all let us know the basic
Understanding of the steroids how the students are doing their action all the hormone estrogen is doing this action when estrogen r0i enters the body the cell the specific cell so there will be a receptor ability for that hormone that steve is or that hormone will then combine with the receptor then this receptor will become activated now this activated receptor
With that specific steroid would inter to the nucleus would be trusted get it to the nucleus inside the nucleus there will be a specific gene which will be then directed for the translation or transcription process to form the protein by meaneth messenger rna then that protein will be formed so this protein will be of to function basic function that is why is growth
Regulation which is the first functional protein and there is proliferation this material be responsible for the cellular growth or several proliferation so now what we are supposed to do as it is causing now it has become the tumor cell so now we want to stop this tumor cell from further growth and proliferation we will inhibit this steroids suppose we have example
Of the drug tamoxifen i am using suppose a lot forgive for that tamoxifen it is a drug that is estrogen receptor antagonist what would disturb do as receptor is going to be activated by the steroids when we take tamoxifen now this t right or this estrogen will not be able to combine with this receptor so if the reception is not going to be combined not going to be
Activated by the drug so what will happen then this tamoxifen will combine with this receptor now this receptor will be not able to go or transfer care towards the nucleus so if it is not coming to the nucleus it is not going to form a protein binding of a transcription and translation now if this protein is not formed so then there will be no growth regulation or
Proliferation of the cell like that we stopped the goat of this tumor or proliferation of this german or these cancer cells then we have relaxation which is also anti tumour that is acting as steroid these are the drugs that will act just is a steerable pathway which will cause the down regulation of estrogen receptor now these drugs they have a common functional
Lattice like they will either stop the receptor to translocate and the next step is that they will form the proteins or they will direct those proteins to target to blink the receptors form the cellular surface to inside the cell before we were having the receptors here now because of these medications what will happen both acceptors present at the surface of the
Cell they will start migrating to inside the cell for the other either those receptors will be destroyed or those receptors will stay inside the cell for a longer period of time so like this if the receptor is not available at the surface so then or inside the cell they are not active or inactive form so then if receptor is not active if sub 2 is not available it
Means that there is no any site of action for that receptor to get itself activate and to go for a reaction for the actions and another one we have an abuti is inhibitor it is also it is a sign which is also responsible for formation of the estrogen extra-adrenal outside the eternal gained in tissues of the skin of the lungs of the breasts of the liver as a trap so
There is of the formation of estrogen so now if we discuss missed estrogens responsive hormone for cancer so we we block this arrow tails then no estrogen will be formed this celebrity is actually fine forming the estrogen by converting and rose send ion to estrogen so if there is no and roasted i own conversion towards estrogen by mean faraday’s like this we would
Not having estrogen these actually happen in postmenopausal woman those women though they have crossed the age 50 or 40 mean now undergoing the process of mini pass they will not be as susceptible for these two types of tumors because estrogen will be also formed in them extra adrenaline so in order to stop extra annual formation of estrogen we will give and
Robotics inhibitors and raloxifene tamoxifen they are actually acting as estrogen antagonist which are acting inside the cell and now i will give you a simple example that is of estrogen regarding the hormone responsive and hormone-dependent now haribo dependent is in the females estrogen hormone dependent means because of this estrogen there is the cancer and
In males is hormone responsive why because in order to treat to the prostate cancer if you want to treat that prostate cancer if we give to that patient estrogen that patient will be triggered means for prostate cancer estrogen is causing regression of the prostate cancer and in case of the breast cancer or any of the cancer especially females if we go under the
Process of surgical procedure or these medications that will cause hormone
Transcribed from video
#7 Anticancer drugs pharmacology |steroids | tamoxifen |raloxifene |aromatsae inhibitors|Dr UUT Eng By Dr UUT lectures doctor uut lectures druutlectures
