3. Treatment of Acute Gout – Anti Gout drugs – Neet PG , Fmge Pharmacology

►𝐉𝐨𝐢𝐧 𝐓𝐡𝐢𝐬 𝐂𝐡𝐚𝐧𝐧𝐞𝐥 𝐓𝐨 𝐆𝐞𝐭 𝐀𝐜𝐜𝐞𝐬𝐬 𝐓𝐨 𝐏𝐞𝐫𝐤𝐬 :-

Now let me discuss about the acute doubt right let me discuss about the acute gout remember this particular acute gout it is manifested as a severe inflammation of the joints all right this is manifested as severe inflammation of the joints and the first joint which is affected is the first metatarsal phalangeal joint and why there is severe inflammation of the

Joints in these patients with the acute gout is this is mainly due to the precipitation of uric acid crystals all right this is mainly due to precipitation of the uric acid crystals within the joint these individuals will have a very severe inflammation now remember what we give in up your gout nsights colchicine and as well as the corticosteroids now the inner

Sides like indomethacin right nsights like indomethacin this is the drug of choice why this is the drug of choice because okay this is the drug of choice because it has better tolerability right this is having a better tolerability but remember any sites like aspirin right nsights like aspirin this should not be given in these patients with the acute gout why

Aspirin should not be given because aspirin will cause hyperuricemia right aspirin vapors hyperuricemia so that is the reason why aspirin is not used now we have another drug which is called as tall mitten this is also an inside and tall mitten this is not effective right this is not effective in the treatment of the gout or the acute gouty attack now apart from

This particular any sides we have the other group of drugs which are called as the politician now you take this particular politician called chisholm as such this is a very effective drug right colchicine this is a more effective and as well as even the fast-acting right as well as the fast-acting compared to that of the nsights but this is used rarely due to its

High toxicity right this is used rarely due to high toxicity right due to high toxicity this is rarely used now how do eat how does this act remember this drug will act by inhibiting right this drug will act by inhibiting the migration of right inhibit inhibiting the migration of the granulocyte to the inflamed joint right it inhibits the chemotaxis right because

The granulocytes once there is the inflame adjoint they will further release the inflammatory mediators that will increase the pain of the individual so the mechanism of action of this particular colchicine is it acts by inhibiting the granulocyte migration to the inflame adjoint now there are two indications for daily use of this colchicine right there are two

Indications for daily use of this particular colchicine now what are these two indications is number one to prevent the further attacks we have to give this daily right to prevent the further attacks we give this particular colchicine daily and the second reason why we give this is this colchicine it should be given along with unit lowering therapy to suppress the

Attacks precipitated by abrupt changes in the serum uric acid right this should be given right colchicine should be given along with you rate lowering drug why we have to give along with the unit lowering drug mainly to suppress the attacks which is precipitated by abrupt changes in the serum uric acid all right now so any sites they’re very good drugs colchicine

They are effective and fast-acting but we don’t give well very commonly because of high toxicity now in refractory cases right you have given any site the pain did not subside you have given colchicine also the pain did not subside so remember in case of refractory cases remember in case of refractory cases what we give is intra-articular corticosteroids right

Intra-articular corticosteroids these are given in case of refractory cases all right now apart from this particular intra-articular corticosteroids colchicine and as well as any sites we have another group of drugs which are used in the management of acute gout they are nothing but introduced in one inhibitors and this interleukin 1 inhibitors what are the

Examples are we have what is called as a knock in rah right we have what is called as the inert indra then we have cannot key new map right cannot key new map this is also an interview in 1 inhibitor and the other drug is real ona set right that the drug is real ona except these have been shown that if you can see for the management of acute curve but these

Drugs some of these drugs they still require the fda approval for giving in case of acute gout alright so in what exactly is the acute gout this is mainly due to the severe inflammation of the joints due to precipitation of the uric acid crystals within the joints and the drugs which are given are the mainly the inner sites like the enemas medicine which is a

Drug of choice which is having a better tolerability and aspirin should never be given because it will further increase the uric acid levels and tal mitten this is not effective in a site in the treatment of acute gout in the other drug which is effective and faster acting is colchicine but this is rarely used because of high toxicity and what this colchicine

Will do is it will inhibit the migration of the granular side to the inflamed joint and there are two indications for daily use of colchicine that is to prevent the further attacks and the colchicine should be given along with the unit lowering drug in order to prevent the abrupt attacks due to change in the uric acid levels in refractory cases what we give is

The intra-articular corticosteroids and the newly approved drugs the further treatment of the acute gout is the interleukin 1 inhibitors that includes the anakinra the kanaky new map and as well as venona set

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3. Treatment of Acute Gout – Anti Gout drugs – Neet PG , Fmge Pharmacology By Dr.G Bhanu Prakash Animated Medical Videos