Hello friends welcome to creative medicine in this lecture we will learn about hello friends let us now learn some important points about sc terminophen what is acetaminophen so acetaminophen is analgesic antipyretic it has analgesic and antipyretic action similar to aspirin but it does not have or it lacks anti-inflammatory action it lacks anti-inflammatory
Effect and one more important thing this acetaminophen is weak inhibitor of both cox1 and cox2 and has minimal or no effect on platelet activity it has no effect on platelet activity it does not antagonize robinson and because it does not antagonize problem acid it can be used in gout okay acetaphinophen can be used in gout unlike the other drugs which cannot
Be used in drought like aspirin cannot be used in gout right uh right now one more important thing is acetaminophen toxicity okay this is us several transactions if you see acetamine no offense acetaminophen will undergo cyp mediated it will undergo cyp mediated and hydroxylation okay and it results in formation of an acetyl para benzoquinone amide okay queen
Zone in mind acetyl parabenzo quinoa is formed okay this is actually it is a highly reactive a relating agent okay and this is detoxified by conjugation with glutamate it will undergo heart sorry glutathione it will undergo conjugated conjugation with glutathione and it is detoxified but if you give very large doses of paracetamol in very large doses of
Paracetamol is a very large doses of paracetamol is taken then you will see that glucurope capacity is saturated this will result in formation of increased quantities or accumulation of an accumulation of increased boundaries of an acetyl para benzoquinone amine naq pqi okay this will applying to the proteins which are present in the liver and it will result
In liver necrosis okay this is one thing next next the effect on alcohol okay whenever there is chronic alcoholism this chronic alcoholism will again it will induce c byp enzymes especially it will induce cyp to e1 and thus this will convert acetaminophen which is nothing but paracetamol as the ketaminophen is paracetamol and it will result in an acetyl paragraph
We don’t image this will lead to toxicity this toxicity is seen on injection of less than 4 grams in alcoholics and if the toxicity is seen more than after more than 7.5 grams ingestion in normal individuals now this is about the toxicity what about the antidote the treatment treatment is nsc tile cysteine is the drug of choice for acetaminophen poisoning how
Does it act this n acetylcysteine this n-acetyl cysteine will replenish the gsh or glutathione stores and once it replenishes the guruther and stores this glutathione stores can conjugate the an acetyl paradox will known iman and thus will okay and and thus it will decrease the um toxic metabolite and one more thing it also has protection it will also converse
Protection against extra hepatic injury how because of its due to its antioxidant and anti-inflammatory property because of its antioxidants and anti-inflammatory property this will show the protection against an extra hepatic injury okay so these are the important points thank you for watching thank you and thank you for watching
Transcribed from video
3 43 acetaminophen mp4 By Creative Medicine
