📌𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-
Now let me discuss about the topic of glaucoma now if you see this particular glaucoma glaucoma it is characterized by increase in the intraocular pressure right it is a clinical condition which is characterized by increase in the intraocular pressure if you take the normal intraocular pressure normal intraocular pressure is around 10 to 21 millimeters of mercury
Right that is a normal intraocular pressure now in patients with glaucoma because of raised intraocular pressure that will cause the progressive damage to the optic nerve right so what is happening in these individuals because of raised intra ocular pressure for longer duration there is progressive damage of the optic nerve right progressive damage of the
Optic nerve next the other important thing is why this particular intraocular pressure is raised now in these individuals the intraocular pressure becomes more than 21 millimeters of mercury right the intraocular pressure will be more than 21 millimeters of mercury now this increase in the intraocular pressure that is the rise in the intraocular pressure or
Intraocular tension it occurs due to two reasons one reason is right one reason is either due to excessive production of the aqueous humor right that is due to excessive production of aqueous humor within the eye or the other reason is the aqueous humor is being produced but it is not drained out properly right so the other reason for increased intraocular
Pressure is because of less drainage right because of the less drainage of the aqueous humor so remember this raised intraocular pressure either it is because of increased production of the aqueous humor or because of less drainage of the aqueous tumor now now you take the drugs which are used in glaucoma right drugs which are used in the treatment of glaucoma
What do they do either they will decrease right either they will decrease the secretion of the aqueous humor or what they do is these drugs they will increase the drainage right they will increase the drainage of the aqueous humor now now what are those group of drugs remember those group of drugs which will decrease the secretion of the aqueous humor are like
These drugs which will decrease the aqua zoomer secretion are number one we have beta blockers that is the very important group of drugs which are used in the treatment of glaucoma and apart from that we have the alpha two agonists and then we have a carbonic anhydrase inhibitors they will also reduce the aquasumer production so the other group of drugs are
Carbonic anhydrase inhibitors so these are the drugs which will decrease the aqueous tumor production the drugs are beta blockers alpha to organisms and as well as the carbonic anhydrase inhibitors next next let me discuss those group of drugs which will increase the outflow the drugs which will increase the outflow of the aqueous humerus like you have myotics
Right which will increase the drainage then we have another important drug that is called dp reference right the other important drug is the dp reference and the other drugs are the prostaglandins so what these drugs will do meiotics dp weffin and as well as prostaglandins they will increase the drainage or by increasing the outflow now now let me discuss the
Individual drugs right what are the examples of the beta blockers what are the examples of the alpha two organisms and carbonic anhydrase inhibitors and then like we have a group of drugs which will increase the drainage now this particular increase in the drainage right this increase in the drainage of the aqua zoomer either it might be because of increase in
The uv scleral outflow right either because of increase in the uvo scleral outflow or the other reason is because of increase in the trabecular outflow right either by increasing the trabecular outflow now let me tell you those group of drugs which will increase the uvsk of drugs which will increase the trabecular outflow now let me tell you the drugs which
Are used in the treatment of glaucoma now we have a group of drugs which will decrease the aqueous human production and we have a group of drugs which will increase the aqueous outflow right the drugs which will increase the aqueous outflow now now let me tell you the group of drugs which will decrease the aqueous humor production the group of drugs which
Will decrease the aqueous secretion or the aqueous humor production is we have beta blockers then we have alpha to agonise and then we have carbonic anhydrase inhibitors okay the group of drugs what we have is number one beta blockers then we have the alpha two agonists and then we have the carbonic anhydrase inhibitors right carbonic anhydrase inhibitors
These are the group of drugs which will decrease the aqua humor production now you take these beta blockers again these beta blockers we have the cardio selective beta blockers and as well as non-selective beta blockers which are used for decreasing the aqueous humor production so these include the cardio selective drugs and the second one is right the second
One is non-selective drugs you take these cardio selective drugs the cardio selective drugs they are betoxylol right we have betoxylor and the other drug is levobitoxilol right the other drug is levobitoxilol so these are the cardio selective beta blockers which will reduce the aqueous humor production next next we have the non-selective beta blockers which
Will reduce the aqua humor production the non-selective beta blockers are right they include timolol is non-selective cardiac selective beta blockers are the one which will act selectively on beta1 receptors right they selectively block the beta 1 receptors whereas non-selective they act on the various other beta receptors as well so these drugs they include
Timalol then we have the another very important drug that is levobinol right levobunylolol and the other important drug that is carteolol okay so these are the non-selective beta blockers which will reduce the aqua tumor production next next we have the alpha two agonists if you take this alpha to agonist they include brimorodin right these drugs they include
Brimonidine and the other one is apraclonadine okay so bremoredin and as well as apraclonadine they act by stimulating the alpha two receptors and thereby they will decrease the aqua tumor production and you take this carbonic anhydrase inhibitors the carbonic anhydrase inhibitors which will reduce the aqueous humor production is we have acetazolamide then we
Have dorzolomite right acetazolamide dorzolomite and as well as brinjalamite right and as well as brainzolomite so these are the group of drugs which will reduce the aqueous humor production by inhibiting the carbonic anhydrase enzyme these are also the group of diuretics as well next you take the group of drugs which will increase the aqueous outflow the
Group of drugs which will increase the aqueous outflow is again the increase in the acquisition outflow is by two types one by increasing the trabecular outflow right by increasing the trabecular outflow and the second one is by increasing the uv scleral outflow right by increasing the uv scleral outflow now you take the group of drugs which will increase the
Trabecular outflow they include pilocarpine they include the physostigmine and the other drug is dp waveframe okay so the drugs are pilocarpine then we have physostigmine and then dp referring okay now you take this particular dp reference dp reference it is an alpha two agonist right it is an alpha two agonist now we have a group of drugs which will increase
The uv scleral outflow and thereby increasing the aqueous outflow the drugs are latino prost right the drugs are the latino prost and the other drug is bimatoprost right the drugs include mainly the latino prost and as well as the bemato prost so these are the drugs which will increase the aqueous outflow right so the group of drugs which are used in the
Treatment of glaucoma are the one which will reduce the aqueous humor production and the drugs which will increase the aqueous outflow and thereby these particular drugs what they do they will decrease the intraocular pressure and thereby preventing the optic nerve damage
Transcribed from video
1.Classification of drugs used in Glaucoma – ANS Pharmacology By Dr.G Bhanu Prakash Animated Medical VideosliveBroadcastDetails{isLiveNowfalsestartTimestamp2021-01-21T123014+0000endTimestamp2021-01-21T124528+0000}
